Characterization of the PEG layer of sterically stabilized liposomes: A SAXS study

TitleCharacterization of the PEG layer of sterically stabilized liposomes: A SAXS study
Publication TypeJournal Article
Year of Publication2012
AuthorsVarga, Z, Wacha, A, Vainio, U, Gummel, J, Bóta, A
JournalChemistry and Physics of Lipids
Pagination387 - 392
Date Published2012
ISBN Number0009-3084
KeywordsID02, JUSIFA, Liposomes, Poly(ethylene glycol), Small-angle x-ray scattering, Sterical stabilization, Structural characterization

Synchrotron small-angle X-ray scattering analysis of the bilayer structure of a pharmacologically relevant sterically stabilized liposome system is presented. Describing the electron density profile of the bilayer with the superposition of Gaussian functions, the contribution of the poly(ethylene glycol) (PEG) layers to the total electron density was identified. The changes in the thickness of the PEG layer as well as the distribution of the PEG chains among the outer and inner leaflets of the bilayers were followed by changing the molar ratio of the PEG-lipid and the molar weight of the PEG molecule.

Short TitleLiposomes, lipid biophysics, and sphingolipid research: from basic to translation research.Chemistry and Physics of Lipids