A simple, efficient, and selective deuteration via a flow chemistry approach
| Author | |
| Abstract |
A simple and efficient deuteration methodology has been established for a wide variety of substrates using a continuous flow hydrogenation reactor. The described procedure is many times faster (1 mg min(-1)) compared to literature methods and the purity of the crude product can be as high as 99%. The deuterium Source is D2O, the consumption of which is very low. (C) 2009 Elsevier Ltd. All rights reserved. |
| Year of Publication |
2009
|
| Journal |
Tetrahedron Letters
|
| Volume |
50
|
| Number of Pages |
4372–4374
|
| ISSN Number |
0040-4039
|
| URL |
https://doi.org/10.1016/j.tetlet.2009.05.050
|
| DOI |
10.1016/j.tetlet.2009.05.050
|
| Download citation |