|Title||Role of oligo(malic acid) on the formation of unilamellar vesicles|
|Publication Type||Journal Article|
|Year of Publication||2018|
|Authors||Bóta, A, Wacha, A, Varga, Z, Szigyártó, ICsilla, Kristyán, S, Lőrincz, A, Szabó, P, Kálmán, M, Naszályi-Nagy, L, Mihály, J|
|Journal||Journal of Colloid and Interface Science|
|Keywords||Freeze fracture, Oligo(malic acid), Small-angle X-ray scattering (SAXS), Sterically stabilized vesicle|
Stable unilamellar dipalmitoylphosphatidylcholine vesicles were produced by using oligo(malic acid) and cholesterol. Detailed physico-chemical characterization prove that by using oligo(malic acid) the substitution of PEGylated lipids for sterically stabilization comes possible. The polymer molecules cover the outer surface of spherical-shaped vesicles, and an asymmetrical composition occurs in the two leaflets of the phospholipid bilayer. The oligo(malic-acid) and cholesterol are enriched in the outer side assuring the stabilization of vesicles. Cholesterol plays an important role in the self-assembly of components as it makes the entering of oligomers possible deep into the polar head-region of lipids. The presence of oligo(malic acid) molecules does not induce degradation by hydrolysis of lipid molecules but the vesicle system turns into a sensitive form giving a possibility for pH sensitive targeting. Preliminary investigation on the investigated oligo(malic acid)-stabilized vesicles do not show any toxic effect promising their applicability in the field of liposomal drug delivery.