Continuous-flow retro-Diels–Alder reaction: an efficient method for the preparation of pyrimidinone derivatives

TitleContinuous-flow retro-Diels–Alder reaction: an efficient method for the preparation of pyrimidinone derivatives
Publication TypeJournal Article
Year of Publication2018
AuthorsNekkaa, I, Palkó, M, Mándity, IM, Fülöp, F
JournalBeilstein Journal of Organic Chemistry
Volume14
Pagination318–324
ISSN1860-5397
Abstract

The syntheses of various pyrimidinones as potentially bioactive products by means of the highly controlled continuous-flow retro-Diels–Alder reaction of condensed pyrimidinone derivatives are presented. Noteworthy, the use of this approach allowed us to rapidly screen a selection of conditions and quickly confirm the viability of preparing the desired pyrimidinones in short reaction times. Yields typically higher than those published earlier using conventional batch or microwave processes were achieved.

URLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815275/
DOI10.3762/bjoc.14.20
PubMed ID29507637