Rapid, simple, and efficient deprotection of benzyl/benzylidene protected carbohydrates by utilization of flow chemistry

TitleRapid, simple, and efficient deprotection of benzyl/benzylidene protected carbohydrates by utilization of flow chemistry
Publication TypeJournal Article
Year of Publication2011
AuthorsEkholm, FS, Mándity, IM, Fülöp, F, Leino, R
JournalTetrahedron Letters
Volume52
Pagination1839–1841
ISSN0040-4039
Abstract

A rapid, simple, and efficient deprotection procedure for the deprotection of benzyl- and/or benzylidene protected carbohydrates is described utilizing a continuous flow hydrogenation reactor. The method tolerates both acid- and base sensitive functional groups. The high efficiency, simple work-up, and short reaction time should make this method appealing to researchers working in the fields of carbohydrate chemistry and total synthesis. (C) 2011 Elsevier Ltd. All rights reserved.