Copper-Catalyzed Oxidative Ring Closure and Carboarylation of 2-Ethynylanilides

TitleCopper-Catalyzed Oxidative Ring Closure and Carboarylation of 2-Ethynylanilides
Publication TypeJournal Article
Year of Publication2013
AuthorsSinai, Á, Mészáros, Á, Gáti, T, Kudar, V, Palló, A, Novák, Z
JournalORGANIC LETTERS
Volume15
Pagination5654–5657
ISSN1523-7060
Abstract

A new copper-catalyzed oxidative ring closure of ethynyl anilides with diaryliodonium salts was developed for the highly modular construction of benzoxazines bearing a fully substituted exo double bond. The oxidative transformation includes an unusual 6-exo-dig cyclization step with the formation of C?O and C?C bonds.