Artificial Transporters

We attempt to create a future molecular scaffold, with which highly efficient and selective chloride ion transportation will be feasible. Supramolecular chemistry derived polyamide protein mimetics (foldamers) were developed with various structural and functional properties. We aim to utilize such constructs for the transportation of ions through membranes. The synthesis of foldamers will be carried out in a highly efficient continuous flow peptide synthetizer.

Group leader: 
István Mándity
Research interests: 
  • Development of artificial chloride ion transporters
  • Design, synthesis and characterization of cell penetrating peptides
  • Foldamer chemistry and biology
  • Development of novel flow chemistry technologies
Expertise: 
  • foldamer chemistry
  • continuous-flow synthesis
  • continuous flow reactor development
  • peptide chemistry
Members: 

Group leader

István Mándity's picture
István Mándity

Post-doctoral researcher

Ruth Deme's picture
Ruth Deme

PhD student

Dorottya Bereczki-Szakál's picture
Dorottya Berecz...
Dóra Bogdán's picture
Dóra Bogdán
György Orsy's picture
György Orsy
Nikolett Varró's picture
Nikolett Varró

Undergraduate student

Réka Száraz-Nagy's picture
Réka Száraz-Nagy

Alumni

Bálint Adamis's picture
Bálint Adamis
Dorottya Szalontai's picture
Dorottya Szalontai
Publications: 
2019
G. Orsy, Fülöp, F., and M. I, M., “Continuous-flow catalytic deuterodehalogenation carried out in propylene carbonate”, Green Chemistry, vol. 21, p. 961, 2019.
K. Szilágyi, Hajdu, I., Blachner, B., Lorincz, Z., Balczer, J., Gal, P., Zavodszy, P., .Pirli, C., Balogh, B., Mandity, I. M., Cseh, S., and Dorman, G., “Design and Selection of Novel C1s Inhibitors by In Silico and In Vitro Approaches”, Molecules, vol. 24, no. 20, 2019.
I. Nekkaa, Bogdán, D., Gáti, T., Béni, S., Juhász, T., Palkó, M., Paragi, G., Tóth, G. K., Fülöp, F., and Mándity, I. M., “Flow-chemistry enabled efficient synthesis of β-peptides: backbone topology vs. helix formation”, Chemical communications, vol. 55, pp. 3061–3064, 2019.
B. Nizami, Bereczki-Szakál, D., Varro, N., Battioui, Kel, Nagaraj, V. U., Szigyártó, I. Cs., Mándity, I., and Somfai, T. - B., “FoldamerDB: a database of peptidic foldamers”, Nucleic Acids Research, 2019.
G. Jakab, Bogdan, D., Mazak, K., Deme, R., Mucsi, Z., Mandity, I. M., Noszal, B., Kallai-Szabo, N., and Antal, I., “Physicochemical Profiling of Baicalin Along with the Development and Characterization of Cyclodextrin Inclusion Complexes”, AAPS PHARMSCITECH, vol. 20, no. 8, 2019.
A. Czompa, Pásztor, B. László, Sahar, J. Alizadeh, Mucsi, Z., Bogdán, D., Ludányi, K., Varga, Z., and Mándity, I. M., “Scope and limitation of propylene carbonate as a sustainable solvent in the Suzuki–Miyaura reaction”, RSC Advances, vol. 9, pp. 37818–37824, 2019.
2018
I. Nekkaa, Palkó, M., Mándity, I. M., and Fülöp, F., “Continuous-flow retro-Diels–Alder reaction: an efficient method for the preparation of pyrimidinone derivatives”, Beilstein Journal of Organic Chemistry, vol. 14, pp. 318–324, 2018.
A. Szloszár, Mándity, I. M., and Fülöp, F., “Sustainable synthesis of N-methylated peptides in a continuous-flow fixed bed reactor”, Journal of Flow Chemistry, pp. 1–7, 2018.
2017
G. Veres, Fejes-Szabó, A., Zádori, D., Nagy-Grócz, G., László, A. M., Bajtai, A., Mándity, I. M., Szentirmai, M., Bohár, Z., Laborc, K., Szatmári, I., Fülöp, F., Vécsei, L., and Párdutz, Á., “A comparative assessment of two kynurenic acid analogs in the formalin model of trigeminal activation: a behavioral, immunohistochemical and pharmacokinetic study”, Journal of Neutral Transmission, vol. 124, pp. 99–112, 2017.
Á. Horváth, Menghis, A., Botz, B., Borbély, É., Kemény, Á., Tékus, V., Csepregi, J. Zsófia, Mócsai, A., Juhász, T., Zákány, R., Bogdan, D., Matyus, P., Keeble, J., Pintér, E., and Helyes, Z., “Analgesic and Anti-Inflammatory Effects of the Novel Semicarbazide-Sensitive Amine-Oxidase Inhibitor SzV-1287 in Chronic Arthritis Models of the Mouse”, Scientific reports, vol. 7, p. 39863, 2017.

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