Artificial Transporters

We attempt to create a future molecular scaffold, with which highly efficient and selective chloride ion transportation will be feasible. Supramolecular chemistry derived polyamide protein mimetics (foldamers) were developed with various structural and functional properties. We aim to utilize such constructs for the transportation of ions through membranes. The synthesis of foldamers will be carried out in a highly efficient continuous flow peptide synthetizer.

Group leader: 
István Mándity
Research interests: 
  • Development of artificial chloride ion transporters
  • Design, synthesis and characterization of cell penetrating peptides
  • Foldamer chemistry and biology
  • Development of novel flow chemistry technologies
Expertise: 
  • foldamer chemistry
  • continuous-flow synthesis
  • continuous flow reactor development
  • peptide chemistry
Members: 
István Mándity's picture
István Mándity 		Ruth Deme
Dóra Bogdán's picture
Dóra Bogdán
Dorottya Szakál's picture
Dorottya Szakál
Publications: 
2017
G. Veres, Fejes-Szabó, A., Zádori, D., Nagy-Grócz, G., László, A. M., Bajtai, A., Mándity, I., Szentirmai, M., Bohár, Z., Laborc, K., Szatmári, I., Fulop, F., Vécsei, L., and Párdutz, Á., “A comparative assessment of two kynurenic acid analogs in the formalin model of trigeminal activation: a behavioral, immunohistochemical and pharmacokinetic study”, Journal of Neutral Transmission, vol. 124, pp. 99–112, 2017.
Á. Horváth, Menghis, A., Botz, B., Borbély, É., Kemény, Á., Tékus, V., Csepregi, J. Zsófia, Mócsai, A., Juhász, T., Zákány, R., Bogdan, D., Matyus, P., Keeble, J., Pintér, E., and Helyes, Z., “Analgesic and Anti-Inflammatory Effects of the Novel Semicarbazide-Sensitive Amine-Oxidase Inhibitor SzV-1287 in Chronic Arthritis Models of the Mouse”, Scientific reports, vol. 7, p. 39863, 2017.
M. Laitaoja, Isoniemi, S., Valjakka, J., Mándity, I. M., and Jänis, J., “Deciphering metal ion preference and primary coordination sphere robustness of a designed zinc finger with high-resolution mass spectrometry”, Protein Science, vol. 26, pp. 198–207, 2017.
L. Kiss, Mandity, I. M., and Fulop, F., “Highly functionalized cyclic beta-amino acid moieties as promising scaffolds in peptide research and drug design.”, Amino Acids, vol. 49, p. 1441, 2017.
R. Samavati, Zador, F., Szucs, E., Tuka, B., Martos, D., Veres, G., Gaspar, R., Mandity, M. I., Fulop, F., Vécsei, L., Benyhe, S., and Borsodi, A., “Kynurenic acid and its analogue can alter the opioid receptor G-protein signaling after acute treatment via NMDA receptor in rat cortex and striatum”, Journal of the Neurological Sciences, vol. 376, pp. 63–70, 2017.
M. Atia, Bogdan, D., Brügger, M., Haider, N., and Matyus, P., “Remarkable regioselectivities in the course of the synthesis of two new Luotonin A derivatives”, Tetrahedron, vol. 73, no. 23, pp. 3231 - 3239, 2017.
2016
B. Fekete, Palko, M., Mándity, I., Haukka, M., and Fulop, F., “A Domino Ring-Closure Followed by Retro-Diels-Alder Reaction for the Preparation of Pyrimido[2,1-a]isoindole Enantiomers”, European Journal of Organic Chemistry, vol. 2016, pp. 3519–3527, 2016.
Z. Hegedüs, Makra, I., Imre, N., Hetényi, A., Mándity, I. M., Monostori, É., and Martinek, T. A., “Foldameric probes for membrane interactions by induced β-sheet folding”, Chemical Communications, vol. 52, pp. 1891–1894, 2016.
I. M. Mándity, Ötvös, S. B., Szolosi, G., and Fülöp, F., “Harnessing the Versatility of Continuous-Flow Processes: Selective and Efficient Reactions”, Chemical Record, vol. 16, pp. 1018–1033, 2016.
E. Riethmüller, Könczöl, A., Szakál, D., Végh, K., Balogh, G. T., and Kéry, Á., “HPLC-DPPH Screening Method for Evaluation of Antioxidant Compounds in Corylus Species.”, Natural product communications, vol. 11, p. 641, 2016.

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