We attempt to create a future molecular scaffold, with which highly efficient and selective chloride ion transportation will be feasible. Supramolecular chemistry derived polyamide protein mimetics (foldamers) were developed with various structural and functional properties. We aim to utilize such constructs for the transportation of ions through membranes. The synthesis of foldamers will be carried out in a highly efficient continuous flow peptide synthetizer.
Group leader:
Research interests:
- Development of artificial chloride ion transporters
- Design, synthesis and characterization of cell penetrating peptides
- Foldamer chemistry and biology
- Development of novel flow chemistry technologies
Expertise:
- foldamer chemistry
- continuous-flow synthesis
- continuous flow reactor development
- peptide chemistry
Members:
Group leader
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Post-doctoral researcher
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PhD student
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Undergraduate student
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Alumni
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Publications:
| , “Continuous-flow catalytic deuterodehalogenation carried out in propylene carbonate”, Green Chemistry, vol. 21, p. 961, 2019. |
| , “Flow-chemistry enabled efficient synthesis of β-peptides: backbone topology vs. helix formation”, Chemical CommunicationsChemical Communications, vol. 55, 2019. |
| , “Continuous-flow retro-Diels–Alder reaction: an efficient method for the preparation of pyrimidinone derivatives”, Beilstein Journal of Organic Chemistry, vol. 14, pp. 318–324, 2018. |
| , “Sustainable synthesis of N-methylated peptides in a continuous-flow fixed bed reactor”, Journal of Flow Chemistry, pp. 1–7, 2018. |