We attempt to create a future molecular scaffold, with which highly efficient and selective chloride ion transportation will be feasible. Supramolecular chemistry derived polyamide protein mimetics (foldamers) were developed with various structural and functional properties. We aim to utilize such constructs for the transportation of ions through membranes. The synthesis of foldamers will be carried out in a highly efficient continuous flow peptide synthetizer.
Group leader:
Research interests:
- Development of artificial chloride ion transporters
- Design, synthesis and characterization of cell penetrating peptides
- Foldamer chemistry and biology
- Development of novel flow chemistry technologies
Expertise:
- foldamer chemistry
- continuous-flow synthesis
- continuous flow reactor development
- peptide chemistry
Members:
Group leader
István Mándity |
Post-doctoral researcher
Ruth Deme |
PhD student
Dorottya Berecz... | Dóra Bogdán | György Orsy | Nikolett Varró |
Undergraduate student
Réka Száraz-Nagy |
Alumni
Bálint Adamis | Dorottya Szalontai |
Publications:
“Continuous-flow catalytic deuterodehalogenation carried out in propylene carbonate”, Green Chemistry, vol. 21, p. 961, 2019. | ,
“Design and Selection of Novel C1s Inhibitors by In Silico and In Vitro Approaches”, Molecules, vol. 24, no. 20, 2019. | ,
“Flow-chemistry enabled efficient synthesis of β-peptides: backbone topology vs. helix formation”, Chemical communications, vol. 55, pp. 3061–3064, 2019. | ,
“FoldamerDB: a database of peptidic foldamers”, Nucleic Acids Research, 2019. | ,
“Physicochemical Profiling of Baicalin Along with the Development and Characterization of Cyclodextrin Inclusion Complexes”, AAPS PHARMSCITECH, vol. 20, no. 8, 2019. | ,
“Scope and limitation of propylene carbonate as a sustainable solvent in the Suzuki–Miyaura reaction”, RSC Advances, vol. 9, pp. 37818–37824, 2019. | ,
“Continuous-flow retro-Diels–Alder reaction: an efficient method for the preparation of pyrimidinone derivatives”, Beilstein Journal of Organic Chemistry, vol. 14, pp. 318–324, 2018. | ,
“Sustainable synthesis of N-methylated peptides in a continuous-flow fixed bed reactor”, Journal of Flow Chemistry, pp. 1–7, 2018. | ,
“A comparative assessment of two kynurenic acid analogs in the formalin model of trigeminal activation: a behavioral, immunohistochemical and pharmacokinetic study”, Journal of Neutral Transmission, vol. 124, pp. 99–112, 2017. | ,
“Analgesic and Anti-Inflammatory Effects of the Novel Semicarbazide-Sensitive Amine-Oxidase Inhibitor SzV-1287 in Chronic Arthritis Models of the Mouse”, Scientific reports, vol. 7, p. 39863, 2017. | ,