Dispersion and stabilization of cochleate nanoparticles

TitleDispersion and stabilization of cochleate nanoparticles
Publication TypeJournal Article
Year of Publication2017
AuthorsBozó, T, Wacha, A, Mihály, J, Bóta, A, Kellermayer, MSZ
JournalEuropean Journal of Pharmaceutics and Biopharmaceutics
Pagination270 - 275

Abstract Cochleates, calcium-stabilized membrane rolls of nanoscale diameter, promise a unique and efficient way of delivering lipid-soluble drugs, proteins or nucleic acids into biological systems because they protect the encapsulated material against enzymatic or chemical degradation. Self-aggregation, which typically arises during production and storage is a major obstacle that has so far precluded the development of an efficient cochleate-based drug-delivery system. Here we show that citric acid, added transiently in a narrow concentration range, effectively disperses cochleate aggregates, stabilizes the disperse state for long-term storage and preserves the canonical ultrastructure and topological characteristics of cochleate nanoparticles.