|Title||Dispersion and stabilization of cochleate nanoparticles|
|Publication Type||Journal Article|
|Year of Publication||2017|
|Authors||Bozó, T, Wacha, A, Mihály, J, Bóta, A, Kellermayer, MSZ|
|Journal||European Journal of Pharmaceutics and Biopharmaceutics|
|Pagination||270 - 275|
Abstract Cochleates, calcium-stabilized membrane rolls of nanoscale diameter, promise a unique and efficient way of delivering lipid-soluble drugs, proteins or nucleic acids into biological systems because they protect the encapsulated material against enzymatic or chemical degradation. Self-aggregation, which typically arises during production and storage is a major obstacle that has so far precluded the development of an efficient cochleate-based drug-delivery system. Here we show that citric acid, added transiently in a narrow concentration range, effectively disperses cochleate aggregates, stabilizes the disperse state for long-term storage and preserves the canonical ultrastructure and topological characteristics of cochleate nanoparticles.