Kinetic studies on the manganese(II) complex catalyzed oxidation of epinephrine

TitleKinetic studies on the manganese(II) complex catalyzed oxidation of epinephrine
Publication TypeJournal Article
Year of Publication2013
AuthorsSzigyártó, ICs., Szabó, L, Simándi, LI
JournalJournal of Molecular Catalysis A: Chemical
Pagination66 - 71
Date Published2013
ISBN Number13811169 (ISSN)
KeywordsCatechol oxidase, Epinephrine, Functional model, Kinetic studies, Kinetic study, Kinetic theory, Kinetics, Manganese, Manganese complexes, Manganese(II) complex, Oxidation, Reaction kinetics

The manganese complex [Mn2(HL)2](BPh 4)2 was found to be a selective catalyst for the oxidation of epinephrine (a catecholamine derivative) to adrenochrome at room temperature in sodium carbonate-bicarbonate buffer. The epinephrine auto-oxidation rate significantly increases upon the addition of manganese complex. The kinetics of reaction was studied by spectrophotometric method, monitoring the increase in concentration of adrenochrome product. According to the proposed mechanism, O2 binding to the manganese complex is followed by the formation of a ternary catalyst-dioxygen-substrate complex as active intermediate, which decomposes in a rate-determining step, generating the adrenochrome. © 2013 Elsevier B.V.

Short TitleJ. Mol. Catal. A Chem.