Separation and identification of tofisopam stereoisomers by hyphenated HPLC-CD technique

TitleSeparation and identification of tofisopam stereoisomers by hyphenated HPLC-CD technique
Publication TypeJournal Article
Year of Publication1999
AuthorsZsila, F, Gergely, A, Horváth, P, Szász, G
JournalJournal of Liquid Chromatography and Related Technologies
Volume22
Issue5
Pagination713 - 719
Date Published1999
Abstract

The published method allows the separation of the four isomers of the anxiolytic 2,3-diazepine derivative, tofisopam. Assignment for the peaks of the two central and two helical isomers is performed by using the chromatogram of the pure tofisopam enantiomers and also considering the conformer-equilibrium was suggested by previous authors. The detection has been made by CD. The in situ CD spectra of the peaks, obtained by stop-flow method, definitely show different chiral character.

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