Novel chiroptical methods in pharmaceutical analysis

TitleNovel chiroptical methods in pharmaceutical analysis
Publication TypeJournal Article
Year of Publication1999
AuthorsGergely, A, Hegedus, H, Horváth, P, Noszál, B, Szász, G, Zsila, F
JournalActa Pharmaceutica Hungarica
Pagination128 - 134
Date Published1999

Chiroptical spectroscopy, and its double and triple hyphenated combinations with UV-VIS spectroscopy and/or separation techniques constitute great progress in pharmaceutical analysis, of which five recently developed methods are surveyed here, as follows: The determination of enantiomeric purity by double, CD/UV detection without, and with the latter one provides enhanced sensitivity and selectivity. The determination of chromatographic peak homogenity, by double detection, and peak slicing by recording. The separation, identification and four stereoisomers of doubly chiral compounds, by HPLC separation on chiral column, and optical-chiroptical detection.