|Title||Novel chiroptical methods in pharmaceutical analysis|
|Publication Type||Journal Article|
|Year of Publication||1999|
|Authors||Gergely, A, Hegedus, H, Horváth, P, Noszál, B, Szász, G, Zsila, F|
|Journal||Acta Pharmaceutica Hungarica|
|Pagination||128 - 134|
Chiroptical spectroscopy, and its double and triple hyphenated combinations with UV-VIS spectroscopy and/or separation techniques constitute great progress in pharmaceutical analysis, of which five recently developed methods are surveyed here, as follows: The determination of enantiomeric purity by double, CD/UV detection without, and with the latter one provides enhanced sensitivity and selectivity. The determination of chromatographic peak homogenity, by double detection, and peak slicing by recording. The separation, identification and four stereoisomers of doubly chiral compounds, by HPLC separation on chiral column, and optical-chiroptical detection.