|Title||Absolute configuration of two new 6-alkylated a-pyrones (= 2H-pyran-2-ones) from Ravensara crassifolia|
|Publication Type||Journal Article|
|Year of Publication||2001|
|Authors||Raoelison, GE, Terreaux, C, Queiroz, EF, Zsila, F, Simonyi, M, Antus, S, Randriantsoa, A, Hostettmann, K|
|Journal||Helvetica Chimica Acta|
|Pagination||3470 - 3476|
The stem bark CH2Cl2 extract of Ravensara crassifolia showed antifungal activity against the phytopathogenic fungus Cladosporium cucumerinum in a bioautographic TLC assay. Activity-guided fractionation afforded two new a-pyrones: (6S)-5,6-dihydro-6-[(2R)-2-hydroxy-6-phenylhexyl]-2H-pyran-2-one (1) and (6R)-6[(4R,6R)-4,6-dihydroxy-10-phenyldec-1-enyl]-5,6-dihydro-2H-pyran-2-one (2). Their structures and absolute configurations were established by NMR spectroscopy, chemical methods, and CD spectroscopy. The antifungal activity against C. cucumerinum was determined for both compounds.