@article{139,
  keywords = {DPPC, Freeze-fractured transmission electron-microscopy (FF-TEM), Kratky camera, Non-bilayer lipid structure, Small- and wide-angle X-ray scattering (SWAXS), Ursolic acid},
  author = {András Lőrincz and Judith Mihály and Csaba Németh and András Wacha and Attila Bóta},
  title = {Effects of ursolic acid on the structural and morphological behaviours of dipalmitoyl lecithin vesicles},
  abstract = {<p>Effects of ursolic acid on the structural and morphological characteristics of dipalmitoyl lecithin(DPPC)-water system was studied by using differential scanning calorimetry (DSC), small- and wide-angle X-ray scattering (SWAXS), freeze-fracture method combined with transmission electron-microscopy (FF-TEM) and infrared spectroscopy (FT-IR). The surface of the uncorrelated lipid system is rippled or grained and a huge number of small, presumably unilamellar vesicles are present if the UA/DPPC molar ratio is 0.1 mol/mol or higher. Besides the destroyed layer packing of regular multilamellar vesicles, non-bilayer (e.g. cubic or hexagonal) local structures are evidenced by SAXS and FF-TEM methods. The ability of UA to induce non-bilayer structures in hydrated DPPC system originates from the actual geometry form of associated lipid and UA molecules as concluded from the FT-IR measurements and theoretical calculations. Beside numerous beneficial e.g. chemopreventive and chemotherapeutic effect of ursolic acid against cancer, their impact to modify the lipid bilayers can be utilized in liposomal formulations.</p>},
  year = {2015},
  journal = {Biochimica et Biophysica Acta - Biomembranes},
  volume = {1848},
  pages = {1092-1098},
  month = {2015},
  isbn = {0005-2736},
  url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84923070939&partnerID=40&md5=1e9ee3841a9273c0536a87417fc09bf5},
  note = {Export Date: 8 February 2016},
}