@article{118,
  author = {B. Fekete and M. Palko and István Mándity and M. Haukka and Ferenc Fülöp},
  title = {A Domino Ring-Closure Followed by Retro-Diels-Alder Reaction for the Preparation of Pyrimido[2,1-a]isoindole Enantiomers},
  abstract = {A simple method was developed to prepare pyrimido[2,1-a]isoindole derivatives by using di-endo- and di-exo-ethyl 3-aminobicyclo[2.2.1]hept-5-ene-2-carboxylate enantiomers as chiral sources. The method is based on a domino ring-closure reaction of norbornene 2-aminohydroxamic acid followed by microwave-induced retro-Diels-Alder reaction. In the case of enantiomeric starting substances, the chirality is transferred from norbornene derivatives to pyrimido[2,1-a]isoindoles. The configurations of the synthesized compounds were determined by 1D and 2D NMR spectroscopy [based on 2D NOE cross-peaks and (3)J(H,H) coupling constants] and X-ray crystallography.},
  year = {2016},
  journal = {European Journal of Organic Chemistry},
  volume = {2016},
  number = {21},
  pages = {3519–3527},
  address = {[Anonymous], 2013, CRYSALISPRO},
  issn = {1434-193X},
}